Objective: Four kinds of different active ingredients from the fruiting bodies from different varieties of Ganoderma lucidum have been detected. The experimental data could be used as the basis of the special medicinal varieties breeding. Method: The content of total polysaccharides

triterpenoid and protein was determined by UV spectrophotometer. Ergosterol was determined by HPLC. Result: Total polysaccharides

triterpenoid and protein were the main components of different sources of Ganoderma lucidum. Ergosterol content was very low in the fruiting bodies. The content of the four ingredients was significantly different in different sources of G. lucidum. In addition

there were no correlations among the content of these four ingredients. Conclusion: Determination of polysaccharides

triterpenoid and protein was meaningful in the quality control of G. lucidum

and it can provide scientific basis for the breeding of special varieties.