Objective: To study the protective effect of traditional Chinese medicine Liuyueqing polysaccharide(LYQP) on duck liver injury induced by duck hepatitis B virus(DHBV)

and provide an experimental base for research and developing a new durg for anti-HBV. Method: Liver injury induced by DHBV in Guangxi brown spotted ducks was used as animal model. Alanine aminotransferase(ALT)

aspartate aminotransferase(AST)

DHBsAg and DHBeAg in serum were detected before treatment(T0)

7 days(T7)

14 days(T14)after treatment

and 3 days after stopping treatment.The extent of liver injury was observed by HE staining. Result: Compared with modle group

the serum levels of ALT

AST

DHBsAg and DHBeAg were decreased significantly (P<0.05 or P<0.01) and at 3 days after stopping treatment

the ALT

AST

DHBsAg and DHBeAg in serum in high-dose and middle-dose did not return. HE staining showed that LYQP had significant protective effects against the duck liver injury induced by DHBV. Conclusion: LYQP has a protective effect against the duck liver injury induced by DHBV.