Objective: To study mechanism of Qingzhuo Anzhong decotion in treating splenogastric hygropyrexia syndrome(SHS) of chronic gastritis. Method: The 50 rats were randomly divided into normal control group

gastritis splenasthenic syndrome group

gastritis splenogastric hygropyrexia group

traditional Qingzhuo Anzhong decoction high dose

low dose 2

1 g ·kg-1 ·d-1 prevention and cure group. The rats were given corresponding drugs by intragastric administration for 20 days.The gastritis splenasthenic syndrome model

gastritis damp-heat syndrome model

and gastritis damp-heat syndrome model were induced by mean of 2%sodium salicylate

honey

fats

senna leaf

the artificial climate box and Qingzhuo Anzhong decoction. The inflammation situation of gastric mucosa were observed by using gastroscope and common pathological staining method. The protein expression of gastric mucosa Bcl-2 was detected by immunohisochemistry. The cell apoptosis of gastric mucosa was detected by the home position terminal sign notation. Result: There all were lightly-hyperphlogosis

apoptotic index being 0.236±0.021

Bcl-2 proteinum expression 0.247±0.041 in 10 rats of splenogastric hygropyrexia group.The gastritis damp-heat syndrome rat model appeared some symptoms and physical sign. The rat gastritis splenic asthenia group and gastritis moist heat group were quite serious in gastric mucosa inflammation

compared with the normal group

the difference was significant (P<0.05). In SHS group Bcl-2 protein expresses was more obvious than that in splenic asthenia group and the normal group (P<0.05). The cell apoptosis index of SHS group and splenasthenic syndrome group was larger than the normal group (P<0.05)

but SHS group was lower than spleen asthenic syndrome group (P<0.05). Conclusion: Adjusting apoptosis

Bcl-2 protein expresses may be one of mechanisms of Qingzhuo Anzhong decoction.