Objective: To observe the influence of Shexiang Baoxin Pills (SBP) on the plasma n-terminal-pro-brain natriuretic peptide(NT-proBNP) and the cardiac function in patients with chronic heart failure. Method: Eighty-four patients of chronic heart failure caused by coronary heart disease were randomly divided into treatment and control group (n=42 each). The control group was applied with routine treatment and the treatment group was given the routine treatment and SBP. After four weeks

the level of plasma NT-proBNP and the cardiac function were detected. Result: Compared with those before treatment

left ventricular end distolic diameter(LVEDD)

left ventricular ejection fraction(LVEF)

cardiac output(CO) and left ventricular and systolic diameter(LVESED) were improved obviously in both groups. However

these indices in the treatment group were better than those in the control group(P<0.05

P<0.01).As plasma NT-proBNP was concerned

the reduce in the treatment group was more significantly than that of the control group(P<0.05).The clinical efficacy of the treatment group was more significantly than that of the control group(P<0.05). Conclusion: SBP can significantly enhance the cardiac systolic and diastolic function and decrease plasma level of NT-proBNP.