Objective: To evaluate the clinical effect of Shenxiong glucose injection on vascular dementia and arginine vasopressin(AVP). Method: We chose 60 cases hospitalized patients according to the selection criteria

and randomLy divided into the treatment group of 30 cases and control group of 30 cases. On the basis of cell diphosphate choline sodium injection

the treatment group was given Shenxiong Glucose injection 200 mL

once daily

the control group was give Shuxuening injection 20 mL

once daily. The course lasted for 28 days. patients’ MMSE

ADL

Chinese medicine symptom scores

hemorrheologic indices and AVP content were observed. Result: ① In MMSE

ADL

Chinese medicine symptom scores before and after treatment

there was significant differences (P<0.05) between two groups; ②In MMSE

ADL

Chinese medicine symptom scores after treatment of one day between the two groups there was no significant difference; ③the whole blood viscosity

plasma viscosity

the red cell aggregation index

fibrinogen after treatment showed significant difference (P<0.05)

suggesting two groups can both improve blood rheology; But action of Shengxiong glucose injection was better than Shuxuening in degrading fibrinogen.④In treatment group plasma AVP content onday 29 of treatment is higher significantly than before treatment(P<0.05)

and the control group has no obvious changes

indicating that the treatment group have an effect on AVP. Conclusion: Shenxiong glucose injection has a good effect on VD patient

which is correlate with AVP.