Objective:To observe the curative effect of Feixianfang on pulmonary fibrosis of rat model induced by bleocamicina. Method: One hundred and forty four healthy rats were randomly divided into six groups: normal group

model group

positive control group

Feixainfang high dose

middle dose and low dose group

24 rats each group. The model were made with Szapiel's method

and the next day all rats were given the corresponding drugs with intragastric administration. The three treatment groups were given to high

middle and low dose of Feixianfang (3.2

1.6

0.8 g·kg-1)

positive control group was given to prednisone acetate (6 mg·kg-1). And normal group and model group were given normal saline

once a day

and the treatment lasted 21 days. Lungs were collected at the 7th day(10 rats)

14th day(4 rats)

and 21st day (10 rats)respectively. Result: Compared with model group

high dose treatment group showed significant difference in improving lung coefficient

increasing glutathione peroxidase(GSH-Px) and superoxide dismutase(SOD) and decreasing malondialdehyde(MDA)

nitrogen oxide(NO)

transforming growth factor-β1(TGF-β1)

platelet derived growth factor(PDGF) and tumor necrosis factor-α(TNF-α) (P＜0.05 or P＜0.01). Middle and low dose treatment group had the same effect as positive control group. And positive control group was better firstly than treatment group

but worse in intermediate stage and later stage. This directed that high dose treatment group had better effect than positive control group markedly

and the long-term effect was superior to prednisone acetate. Conclusion: Feixianfang is an effective formula in treating and preventing pulmonary fibrosis. It can intervene in the injury caused by bleocamicina with dose-effect relationship.