Objective: To study the hypoglycemic effect of Yikang capsules in the diabetic mouce and rat model. Method: Alloxan were injected in ICR mice (85 mg·kg-1) and SD rats (60 mg·kg-1) by Intravenous injection

then the diabetic model was established after 72 h. ICR mice and SD rats were divided into seven groups randomly

Yikang capsules high

medium and low dose groups

control group

model control group

positive control group (metformin hydrochloride)

Jinqi tablet control group. and corresponding drugs were given for 11 days

then the glucose tolerance was observed. Result: Yikang capsules high

medium and low-dose showed hypoglycemic action in diabetic ICR mice. Compared with the model group

there was significant difference in blood glucose level(P<0.01). Hypoglycemic percentage was 23.8%

21.1%and 18.7%

respectively. Yikang capsules could significantly inhibit the increased blood glucose at the day 11 of administration and at 24 hours of withdrawal; Yikang capsules could improve the glucose tolerance of the normal mice. Conclusion: Yikang capsules has a hypoglycemic action in diabetic ICR mouce and rat model induced by alloxan

and can improve the glucose tolerance of normal mice.