Objective: To study the effect of Compound Ginseng Brain Tonic Liquid (CGBTL) on cerebral ischemia-reperfusion injury. Method: Rats were randomly divided into normal control group

cerebral ischemia and reperfusion model group

large drug dose + model group (CGBTL 10 g·kg-1)

small drug dose + model group (CGBTL 5 g·kg-1)

vitamin E + model group. The model of cerebral ischemia reperfusion rats was established by ligaturing carotid. The lipid peroxide content of brain cell was measured with thiobarbituric acid. Reduced glutathione was determined by the method of spectrophotometer. Oxygen consumption was measured with clark oxygen electrode method. Result: In rats with cerebral ischemia-reperfusion injury

there showed an increase in lipid peroxide content (P <0.001)

a decrease in reduced glutathione (P<0.001) and an increase in oxygen consumption (P<0.001) compared with those in the normal control group. In CGBTL large dose and small dose groups

compared with the model group

there showed a decrease in lipid peroxide content (P <0.001)

and an increase in reduced glutathione content (P <0.001) and a decrease in oxygen consumption (P<0.001). In vitamin E treatment group

the outcomes were significant (P <0.001). Conclusion: CGBTL has preventive effect on cerebral ischemia-reperfusion injury.