Objective: To study effect of Pingmin Granule (PMG) on chronic eczema and its impact on tumor necrosis factor 2α(TNF-2α)

soluble inter leukin 2 thereceptor(slL-2R) and eosinophil cationic protein(ECP) levels. Method: The effects of PMG and cetirizine on chronic eczema patients in two groups were observed respectively

and the serum levels of TNF-2α

slL-2R and ECP were measured by ELISA before and after treatment. Result: In PMG group effective rate was 86.1% vs 54.3%(cetirizine) and recurrence rate was 8.0% vs 44.4% (cetirizine)(all P<0.05). Serum levels of TNF-2α

slL-2R and ECP in patients were higher than those in normal subjects(P<0.01)

and PMG group could be significantly lower than cetirizine group in the serum of patients with TNF-2α[(36.93±9.51)

(42.83±11.72)ng·L-1

(P<0.05)]

sIL-2R[(46.42±10.61)

(53.34±15.66)μg·L-1

(P<0.05)]

ECP[(25.81±9.64)

(30.16±8.68)μg·L-1

(P<0.05)]after treatment. Conclusion: PMG has effect on chronic eczema

its regulation on serum levels o f TNF-2α

slL-2R and ECP may be the mechanism of action.