Objective: The effect of Liuwei Dihuang Wan(LWDH)and Erdong Gao (ED)on the tumorigenesis and the antitumor immune function were studied in a model of chemical carcinogenesis in the mouse lung. Method: Thirty three female Kunming mice with urethane subcutaneous injection(1 g·kg-1·d-1)were randomized into three groups: the control group

the group treated with LWDH(ig

1.56 g·kg-1·d-1)and the group treated with ED(ig

0.78 g·kg-1·d-1). The mice were sacrificed after 100 days to investigate the rate of tumor formation by naked eye

pathological section and hematoxylin-eosin staining.The spleen index

thymus index

activity of macrophage and content of tumor necrosis factor alpha (TNF-α) in the blood serum were tested. Result: In the process of lung carcinogenesis

compared with control group

LWDH and ED could reduce the rate of lung chemical carcinogenesis which was 18.2% and 36.4%

respectively. Compared with control group

LWDH and ED could also increase the spleen index

elevate the activity of macrophage(P<0.05 or P<0.01)and decrease the content of TNF-α in the blood serum(P<0.05 or P<0.01). Conclusion: LWDH and ED can delay the occurrence and development of lung carcinoma induced by urethane through enhancing antitumor immunity and decreasing content of the inflammatory factor.