Objective: To evaluate anti-fatigue and hypoxia tolerance effect of mogrosides in mice. Method: Mice were randomly divvied into normal control group

model control group

positive control group (Hongjingtian capsule

570 mg·kg-1)

mogrosides high dosage (300 mg·kg-1)

medium dosage (150 mg·kg-1) and low dosage groups (75 mg·kg-1). After orally administrated for 21 days consecutively

exhaustive swimming test and atmospheric hypoxia test were employed to evaluate anti-fatigue and hypoxia tolerance effect of mogrosides in mice. Furthermore

liver glycogen and muscle glycogen level were examined

urea nitrogen level

lactic acid level and lactate dehydrogenase activity after swim were determined. Result: Mogrosides significantly extended swimming time (P<0.05)

and extended hypoxia survival time at 75 mg·kg-1 and 150 mg·kg-1 (P<0.05). Moreover

liver glycogen and muscle glycogen level were significantly increased after treatment (P<0.001)

urea nitrogen level

lactic acid level were decreased (P<0.001)

lactate dehydrogenase activity was enhanced (P<0.05). Conclusion: Mogrosides possesses abilities of anti-fatigue and hypoxia tolerance. The effects could be mediated by increased glycogen supplying and improved lactate metabolism.