Objective: To optimize extraction and purification technology of Qionggui Shuloug granule. Method: With transfer rate of ferulic acid as index

water extraction technology of Qionggui Shuloug granule was optimized by orthogonal test

soaking time

extraction times

extraction time and the amount of water were selected as factors

the content of ferulic acid was determined by HPLC;With transfer rate and purity of ferulic acid as indexes

single-factor test was used to investigate alcohol precipitation technology. Result: Optimized extraction technology was:soaked 1 h with 15 times the amount of water

extracted 2 times with 1 h per time;alcohol precipitation technology was:alcohol precipitation to the concentration of ethanol 60%

the relative density of 1.08-1.14(60℃). Conclusion: This optimized technology was stable and feasible

it could provide experimental basis for industrial production of Qionggui Shuloug granule.