Objective:To investigate anti-atherosclerosis effect in rats of the extracts of Radix Salviae Miltiorrhizae(RSM)

Fructus Crataegi(FC)

as well as their interaction. Method:Male Wistar rats were randomly divided into 2 groups:normal group and model group. The atherosclerotic model was established by injection of VD3 and ovalbumin

while fed with high cholesterol diet. After the model was determined successfully

all model rats were divided into normal group

model group

RSM group

FC group

mixture of RSM and FC group. Each group was given the corresponding drug for 4 weeks. After the end of treatment

blood serum were analyzed for blood-fat levels

the contents of MDA

SOD and NO

observing ortic organization morphological changes by the method of(HE) dyeing. Result:The TC

TG

LDL-C and MDA level were reduced

while the HDL-C

the serum SOD

NO were raised in the drug intervention groups. And for many indexes

there was obvious (P<0.05) effect for the mixture of RSM and FC group. Conclusion:RSM and FC show synergistic effect

the combined effect is better.