Objective: To optimize extraction and purification technology for Dahuang Tongqi oral liquid. Method: With volume of volatile oil as index

orthogonal test was used to optimize extraction technology of volatile oil from Aucklandia lappa

Citrus sinensis and so on with soaking time

extraction times

the amount of water as factors;With yield of water extract

total content of rhein

emodin and chrysophanol as indexes

orthogonal test was used to investigate factors of water extraction process for Dahuang Tongqi oral liquid

such as extraction time

extraction times and the amount of water;With yield of dry extract

total extraction ratio of rhein

emodin and chrysophanol as indexes

orthogonal test was used to investigate factors of ethanol precipitation process for Dahuang Tongqi oral liquid

such as relative density of liquid

the concentration of ethanol and alcohol precipitation time. Result: Optimized extraction technology of volatile oil was:distilling 2 h with 4 times the amount of water;optimum water extraction technology was:boiling 2 h with 8 times the amount of water

2 h per time;optimized alcohol precipitation process was:concetrated to relative density of 1.20 (80 ℃)

95% ethanol was added to liquid contained ethanol of 50%

alcohol precipitation time 24 h. Conclusion: Optimized extraction and purification technology for Dahuang Tongqi oral liquid was reasonable and feasible

it was suitable for requirements of industrial production.