Objective: To optimize compatibility extraction technology of Ligusticum chunxiong and Angelica sinensis

and compare the content of ferulic acid in Chinese herbal compound contain L. chunxiong and A. sinensis pair compatibility and single one. Method: With the content of ferulic acid as index which was determined by HPLC

compatibility extraction technology of L. chunxiong and A. sinensis was optimized by orthogonal test design with extraction time

extraction voltage

ethanol consumption and ethanol volume fraction as factors

and optimized process was used to extract L. chunxiong and A. sinensis single

the content variation of ferulic acid were compared in compatibility and single extraction

in order to investigate synergism mechanism of compatibility of L. chunxiong and A. sinensis. Result: Optimum extraction technology was:extracted 1.5 min with 20 times the amount of 65% ethanol

extraction voltage 100 V;The content of ferulic acid in compatibility extraction liquid was similar with the total content in single extraction liquid. Conclusion: This optimized technology was simple and economic

it confirmed that reason for enhancing pharmacological effect of compatibility with L. chunxiong and A. sinensis wasn't because of increasing the content of ferulic acid.