Objective: To optimize one-step granulation technology for Xinjianwei package tablet. Method: With particle hardness

particle size

compressibility

properties and the content of sodium bicarbonate in tablet core as indexes

single-factors test was used to investigate key factors on granulation technology for Xinjianwei package tablet. Result: Granulation technology of Xinjianwei package tablet didn't change original materials

material temperature was 45℃

inlet air temperature was 50-60℃

5% starch slurry as adhesive

under these conditions

prepared particle had excellent compressibility and mobility

package tablet was stability

and the content of sodium bicarbonate had been raised. Conclusion: One-step granulation had very excellent operability

quality of products was stability and was improved

it could provided reference for mass production.