Objective: To investigate the poctect function of Diyu Shengbai tabletts on bone marrow depression induced by cyclophosphamide in mice. Method: Twenty-four Balb/C mice

half male and femal

were categorized into three groups. Mice in model group and Diyu Shengbai group were administered cyclophosphamide (Cy) (100 mg · kg-1 once a day for 3 days by intraperitoneal injection) to induce marrow suppression. Diyu Shengbai group was received Diyu Shengbai table treatment (100 mg · kg-1body weight orally once a day for 10 days). A vehicle treated control group was also arrangeed. The changes of peripheral hemogram

bone marrow nucleated cells (BMCs)

DNA content and bone marrow cell cycle were detected. Result: Cy-treated mice showed a significant decrease in the number of white blood cells

thrombocyte

bone marrow nucleated cell proliferation and the content of DNA in bone (compared with control group

there were significant differences

P<0.05 or P<0.01).The percentage of G0/G1 phase was increased and the percentage G2/M phase decreased (compared with control group

there were significant differences

P<0.05 or P<0.01). Diyu Shengbai tablets significantly increased the number of white blood cells

thrombocyte

bone marrow nucleated cell proliferation and markedly increased the percentage of G2/M phase(compared with model group (P<0.05 or P<0.01). Conclusion: Diyu Shengbai Tablets could improve the hemopoietic function for marrow suppression induced by Cy in mice.