Objective:To explore the influence of Yisui Shengxue granule (YSG) on the kidney medullary loss in mice model induced by radiation damage. Method:Whole body irradiation of 60Coγ-ray was used to induce mice model of kidney medullary loss. The model showed bone marrow hematopoietic inhibition and reduction in visible components in peripheral blood. YSG(23.6

11.8

5.9 g·kg-1

ig) was preventively given 2 days before irradiation and successively given 14 days after irradiation. Peripheral blood indexes were examined before radiation and at the 1

2

5

7

9

11

13

15

17

19 and 21 days after radiation. Result:In the positive drug(G-CSF) group

the WBC count was significantly increased after radiation at the 1-17 days compared with those in model group(P<0.05

P<0.01). The WBC count in three dosage groups of YSG at the 1

5

7

13 and 17 days after radiation was elevated(P<0.05 or P<0.01). The RBC count and hemoglobin were descended to a certain extent after irradiation.The RBC count in the group of positive drug(G-CSF) and all dose groups of YSG was higher than that in the model group(P<0.05 or P<0.01). Platelet count was decreased in the 5 day after radiation and reached the lowest level in the 7 day and then rose slowly in model group. However

the platelet count in the treatment group was rapidly recoveried from the 5 day after radiation

and those in the high dosage group were much higher than those in the model group in 5

11 and 13 days

and that in the medium dosage group in the 13 day was higher than that in the models(P<0.05

P<0.01

P<0.001). Conclusion:All dose groups of YSG can increase the WBC count significantly after radiation damage and promote the RBC

hemoglobin and platelet count recovery. The results suggest that the recipes of promoting kidney and tonifying bone have the function of supplying the kidney essence and protecting marrow and also can promote hematopoietic.