Objective: To evaluate the acute toxicity and the protective effects of Radix Adenophorae Potanini Korsh Polysaccharides dispersible tablets (RPDTS) on acute hepatic injury induced by carbon tetrachloride ( CCl4) in mice. Method: The maximum dosage test was used as intragastric administration in mice to observe acute toxicity of RPDTS. After intragastric administration RPDTS(0.75

1.5

3 g · kg-1)in mice for 7 days

the acute liver injury model was induced by CCl4. The levels of alanine aminotransferase(ALT)

aspartate aminotransferase(AST) in serum and total superoxide dismutase(T-SOD)

malondialdehyde(MDA)

glutathione peroxideobjects enzyme(GSH-Px) in liver were determined by kits respectively. Histopathological examination was also carried out. Result: Acute toxicity test showed that the total dose of intragastric administration of RPDTS was 208 g · kg-1 (according to Adenophorae tetraphylla) equivalent to 120 times the clinical dose for adults. Acute liver injury test showed that RPDTS could obviously decrease the levels of ALT

AST in serum and MDA in liver(P<0.05)

obviously increase the levels of T-SOD

GSH-Px in liver

the histopathological examination indicated that liver injuries were relieved. Conclusion: RPDTS has no acute toxicity

RPDTS has protective effects on acute liver injuries induced by CCl4 in mice.