Objective: To study effect of Xiaoxun decoction (XXD) with acupoint application in treatment of chronic urticaria. Method: Eighty-two cases of chronic urticaria patients were randomly divided into two groups. Observation group(42 cases)were treated with XXD and acupoint application

control group(40 cases) was treated with Clarityne and famotidine tablets. Thirty days in both groups were one course of treatment

and continuous use of three treatment was applied. Symptom scores

serum IgE levels

differences in efficacy and relapse rate were compared before and after treatment in both groups. Result: Compare with the serum IgE levels differences in efficacy in 30

60 days of treatment

the two groups had no significant difference.The treatment group was more effective than the control group in the 90 days of treatment(P<0.05). The therapentic effective rates for the treatment group and control group were 64.3% and 37.5% respectively on the 90th day. Relapse rate in observation group was 11.9%

in control group was 45%

the difference was statistically significant(P<0.05). Conclusion: XXD with acupoint application is effective for the treatment of chronic urticaria.