Objective: To investigate the effects of Shiquan Dabu Tang on Lewis pulmonary metastasis angiogenesis and pulmonary metastasis after primary tumor excision

and explore its possible mechanism and clinical significance. Method: The C57/BL6 mouse Lewis pulmonary metastasis model was established

and mice randomly divided into primary tumor resection group (TR)

primary tumor preserve group (TP) and Shiquan Dabu Tang group (SDT). Microvessel density(MVD) and cell multiplication of pulmonary metastasis was detected with SP immunohistochemical staining. The level of vascular endothelial growth factor (VEGF)

angiostatin (AS) and endostatin (ES) was examined by ELISA assay. Result: The number of pulmonary metastasis

incidence of metastases and MVD were evidently inhibited by Shiquan Dabu Tang. Ki67 expression was significantly lower than control group. Conclusion: The excision of primary tumor can promote pulmonary metastasis angiogenesis and pulmonary metastasis

and application of Shiquan Dabu Tang after operation has instructive clinical significance in preventing tumor metastasis.