Objective: To investigate the effects of Zhishi Xiebai Guizhi Tang on hermorrheology and oxygen free radicala in hyperlipidemia rat. Method: Using hyperlipidemia animal model replicated by hyperlipidemia forage

pravastatin sodium (3.6 mg·kg-1)and different doses of Zhishi Xiebai Guizhi Tang (7.2

3.6

1.8 g·kg-1) were given to rats in model group. Then indexes of hermorrheology

levels of malondialdenhyde(MDA) and superoxide dismutase(SOD) were assayed. Result: Compared with the control group

the whole blood viscosity at the 200 s-1 and 5 s-1 shear rate and plasma viscosity in the model group were increased

the levels of MDA was increased

the level of SOD was decreased obviously. Compared with model group

the level of the whole blood viscosity at the 200 s-1 and 5 s-1 shear rate and plasma viscosity in Zhishi Xiebai Guizhi Tang(high dose) group and the pravastatin sodium group were decreased

the level of MDA was decreased

the level of SOD was increased. Conclusion: The Zhishi Xiebai Guizhi Tang can improve hermorrheology

clean oxygen free radical in rat with hyperlipidemia.