Objective: To investigate the changes of T lymphocyte subsets and endothelial function in early diabetic nephropathy and the effect of Bailing capsule on immune intervention. Method: Sixty patients with early diabetic nephropathy were selected and randomly divided into 2 groups

routine group (n=30) was treated with insulin; the Bailing capsule group (n=30) was treated with Bailing capsule(54)combined with insulin. Thirty healthy as control group. After 8 weeks of treatment

the endothelium-dependent flow-mediated dilatation(FMD) of brachial artery was determined with ultrasound

and the levels of soluble intercellular adhesion molecule-1(sICAM-1)

endothelin-1(ET-1)and T lymphocyte subsets were measured respectively before and after treatment. Result: All patients with early diabetic nephropathy showed that the CD4+T cells

CD4/CD8

sICAM-1

ET-1 was higher than that of the control group(P<0.05)

the CD3+T cells

CD8+T cells and FMD were lower than those of the control group(P<0.05). After treatment the CD4+T cells

CD4/CD8

sICAM-1

ET-1 in the Bailing capsule group[CD4+(37.5.±3.1)%

CD4/CD8(1.56±0.16)

sICAM-1(476±94)μg·L-1

ET-1(167±9.9) ng·L-1] was decreased more significantly than routine group [(41.3±2.8)%

(2.07±0.17)

(509±89)μg·L-1

(201±13.7) ng·L-1] (P<0.05). After treatment the CD3+T cells

CD8+T cells and FMD in the Bailing capsule group was increased more significantly than routine group (P<0.05). Conclusion: The Bailing capsule can effectively regulate the patient’s cellular immunity and recovery vascular endothelial function with early diabetic nephropathy.