Objective: To study the effect of pollen typhae flavonoids on hemorheological parameters and platelet aggregation. Method: Forty-eight female rabbits were divided into normal group (saline)

model group (saline)

Salvia miltiorrhiza group (tanshinone 0.13 g·kg-1)

pollen typhae flavonoids high

median

low dose group (dose of 0.8

0.5

0.2 g·kg-1). Except for the normal group which was given sc saline

other groups were given sc adrenaline hydrochloride and socked in ice-water

so as to establish acute blood stasis model. Then the effect of pollen typhae flavonoids on hemorheological parameters was studied by this model. Based on the platelet aggregation in rabbits

the inhibitory action of pollen typhae flavonoids on the formation of thrombosis was studied. Result: Pollen typhae flavonoids could significantly reduce viscosities at each shear rates and HCT for blood stasis model

there were significant differences (P＜0.05 or P＜0.01)

and could significantly reduce the maximum platelet aggregation rate and shorten the maximum agglutinating time with significant differences (P＜0.01). Conclusion: Pollen typhae flavonoids can obviously ameliorate the hemorheological parameters and inhibit the platelet aggregation.