Objective: To observe the anti-fatigue effect of Lycium barbarum L. on Yin deficiency model mice. Method: Mice were divided randomly into five groups: three treatment groups(L. barbarum orally given for 14 days

5

10

20 g·kg-1 daily)

model group and control group. Mice Yin deficiency model was induced by injecting hydrocortisone

The open field test

lactic acid

urea nitrogen and weight-loaded swimming test with computer-aided automatic control system were used to observe actions of L. barbarum. Result: L. barbarum could increase spontaneous motor activity and descended the level of blood lactic acid and blood urea nitrogen in Yin deficiency model mice(P<0.05). The sink time and the death time in 10

20 g·kg-1groups were significantly prolonged as compared with model group(P<0.05). Conclusion: L. barbarum has anti-fatigue effect in Yin-deficiency model mice. It can increase endurance of mice in later period of swimming.