Objective: To study the influences of Weiweikang granule(WWKG) on the expression of proliferating cell nuclear antigen (PCNA)

epidermal growth factor receptor (EGFR) of gastric mucosa with chronic atrophic gastritis(CAG)

and evaluate the possible mechanisms. Method: Ninety SD rats were randomly divided into five groups. The high dose WWKG group

low dose WWKG group

Sanjiu Weitai granule(SJWTG) group and model group.The multiple stimulations were used to duplicate the CAG model. After modeled successfully

the high dose WWKG group

low dose WWKG group

SJWTG group and model group were intragastrically injected(ig) with WWKG at dose of 6

3 g·kg-1

and SJWTG at dose of 1.6 g·kg-1

respectively and normal saline(0.9%)at dose of 20 mL·kg-1. After 30 days

the rats'stomach mucous membrane atrophy situation was observed with the help of light microscopy and transmission electron microscopy and the expression of PCNA and EGFR were observed with immunohistochemical method. Result: The light microscopy and electron microscopy examination showed that the pathological changes of gastric mucosa in large dose WWKG group and small dose WWKG group were significantly milder than those in the model group. Compared with the control group

the expression of PCNA labeling index(LI 44.96%)and EGFR(average obsorbance

A0.183 ±0.030) in the model group was higher than the normal group (LI 29.30%

A 0.125±0.039)obviously(P<0.01).Compared with the model group

the expression of PCNA and EGFR in large dose WWKG group(LI 29.58%

A 0.100±0.023)and small dose WWKG group (LI 29.97%

A 0.104±0.027)was significantly lower(P<0.05 or P<0.01). Conclusion: WWKG can significantly repair gastric mucosa of rats with CAG and its mechanism may be actualized by decreasing the expression of PCNA and EGFR and restraining cell proliferation and malignant transformation.