Objective: The effect of Ersheng decoction on myocardial ischemia in rats. Method: Wistar rats was randomly divided into 5 groups

Ersheng decoction high dose group

middle dose group

low dose group(100

50

20 g·kg-1)

control group and model group

ten rats in each group. The changes of electrocadiograph (ECG) II lead

serum level of thromboxane A2(TXA2)

prostacylin(PGI2) and the content of Bax mRNA

Bcl-2 mRAN on myocardial cells were detected. Result: Compared with model control group

Ersheng decoction group decreased the T wave(P<0.05)

and could reduce the blood serum content of TXA2

which was significantly lower in Ersheng decoction high dose group (102.16±9.41)μg·L-1 than that in model group(188.81±38.70)μg·L-1 (P<0.05)

increase the serum PGI2 content

which was significantly higher in Ersheng decoction high dose group (112.10±10.45)μg·L-1 than that in model group(36.10±4.26) μg·L-1 (P<0.05); Ersheng decoction could inhibit Bax mRNA expression

up-regulation of Bcl-2 mRNA expression(P<0.05). Conclusion: Ersheng decoction can protect myocardial cells against myocardial ischemia injury

which may be related to regulating expression of Bcl-2 mRNA and Bax mRNA.