Objective: To observe the curative effect

interleukin-12(IL-12) and tumor necrosis factor-α(TNF-α) change by Yiguanjian plusminus in patients chronic atrophic gastritis

for accumulating the clinical experience

directing the clinical work. Method: Eighty-six patients with chronic atrophic gastritis were divided into two groups. The control group(43 cases) were treated by routine treatment

the observation group(43 cases) were added Yiguanjian plusminus. We observated the efficacy and the change of IL-12 and TNF-α in two groups. Result: The total effective rate was obviously higher in the observation group than in the control group. The expressions of IL-12 and TNF-α were obviously lower in the observation group than in the control group after treatment. Conclusion: The Yiguanjian plusminus chinese medicine can improve the curative effect

regulate the expressions of IL-12 and TNF-α in patients with chronic atrophic gastritis

is worthy of being recommended in clinical treatment.