Objective: To explore the anti-fatigue effect and mechanism of polysaccharides from mulberry amylose(MA). Method: A total of 224 Kunming mice were randomly divided into 4 batches

each of which consisted of 4 groups:MA groups at the dosages of low(100 mg·kg-1)

middle(300 mg·kg-1)and high(900 mg·kg-1)

and the control group. Each mouse was administered once a day for 35 days. After the end of the administration

all the mice were evaluated for their weight-loaded swimming duration and the contents of hepatic glycongen

blood urea nitrogen(BUN) and blood lactic acid. Result: MA at the high dosages could prolong weight-loaded swimming duration(31.3±15.13) min

compared with (7.15±2.91) min. In addition

an increase of hepatic glycongen (26.23±6.08) mg·g-1

compared with (18.75±3.12) mg·g-1 and a decline of BUN (9.66±1.35) mmol·L-1

compared with (12.07±1.64) mmol·L-1 were observed in mince administered MA at the high dosages. Conclusion: MA could alleviate physical fatigue.