3种治法方药对2型糖尿病胰岛素抵抗大鼠血液流变学和内皮素的影响

张业; 谢鸣; 刘玥

您当前的位置：

首页 >

文章列表页 >

3种治法方药对2型糖尿病胰岛素抵抗大鼠血液流变学和内皮素的影响

更新时间：2024-09-23

- 3种治法方药对2型糖尿病胰岛素抵抗大鼠血液流变学和内皮素的影响
- The Effect of 3 Kinds of Formulas with Different Therapeutic Methods on Hemorheology and ET-1 Level in Rats with Type 2 Diabetes Insulin Resistance
- 中国实验方剂学杂志 2012年18卷第9期页码：247-250
- 作者机构：
- 作者简介：
- 基金信息：
  
  河南中医学院"博士科研基金"课题(BSJJ2009)
- DOI：
  中图分类号：
- 纸质出版日期：2012
- 稿件说明：
移动端阅览
张业, 谢鸣, 刘玥. 3种治法方药对2型糖尿病胰岛素抵抗大鼠血液流变学和内皮素的影响[J]. 中国实验方剂学杂志, 2012,18(9):247-250.

ZHANG Ye, XIE Ming, LIU Yue. The Effect of 3 Kinds of Formulas with Different Therapeutic Methods on Hemorheology and ET-1 Level in Rats with Type 2 Diabetes Insulin Resistance[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(9): 247-250.
张业, 谢鸣, 刘玥. 3种治法方药对2型糖尿病胰岛素抵抗大鼠血液流变学和内皮素的影响[J]. 中国实验方剂学杂志, 2012,18(9):247-250. DOI：

ZHANG Ye, XIE Ming, LIU Yue. The Effect of 3 Kinds of Formulas with Different Therapeutic Methods on Hemorheology and ET-1 Level in Rats with Type 2 Diabetes Insulin Resistance[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(9): 247-250. DOI：

摘要

目的: 观察不同治法方药对2型糖尿病胰岛素抵抗大鼠血液流变学和内皮素的影响。方法: 高脂饲料喂养5周配合小剂量链脲佐菌素(STZ)ip的方法建立2型糖尿病IR大鼠模型。从第11周

西药吡咯列酮1.35 mg·kg-1·d-1中药干预分别给予益气养阴化痰活血方(中药Ⅰ方:11.61 g·kg-1·d-1)、益气养阴化痰降浊方(中药Ⅱ方:8.46 g·kg-1·d-1)、化痰降浊活血化瘀方(中药Ⅲ方:6.30 g·kg-1·d-1)ig治疗2周。第12周末

用血液流变仪测定全血黏度(200 s-1

5 s-1)、血浆黏度;用放免法检测血浆内皮素(ET-1)。结果: 与模型组比较

吡咯列酮组大鼠血浆比黏度显著降低(P<0.05);中药Ⅰ方、中药Ⅲ方大鼠高切、低切下的全血比黏度与血浆比黏度均显著降低(P<0.05);用药各组对红细胞压积(HCT)均无明显影响;吡咯列酮组和中药干预各组大鼠血浆内皮素(ET-1)含量均显著降低(P<0.05或P<0.01)。结论: 3种不同治法方药对2型糖尿病胰岛素抵抗大鼠内皮细胞损伤和血流变异常有改善作用

并存在有差异性

益气养阴化痰活血方治疗效果较明显。

Abstract

Objective: To investigate the effects of 3 kinds of formulas with different therapeutic methods on hemorheology and endothelin-1 (ET-1) level in rats with type 2 diabetes mellitus(T2DM). Method: The rat model was established by feeding of high glucose and fat diet with peritoneal injection of (STZ). Different formulas were given to the modeling rats. Then indexes of

hemorheology and levels of ET-1 were tested. Result: Compared with the model group

the level of the whole blood viscosity at the 200 s-1

5 s-1 shear rate and plasma viscosity of theⅠformula (Yiqi Yangyin Huatan Huoxue fang) group and the Ⅲ formula (Huatan Jiangzhuo Huoxue Huayu fang) group were decreased obviously

the level of ET-1 of all formulas was decreased obviously. Conclusion: The effect of Ⅰformula (Yiqi Yangyin Huatan Huoxue fang) is the best among the 3 kinds of formulas.The Yiqi Yangyin Huatan Huoxue fang has an improvement effect on hemorheology and endothelial cell injury in rats with type 2 diabetes mellitus.

关键词

Keywords

references

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

3种治法方药对2型糖尿病胰岛素抵抗大鼠血液流变学和内皮素的影响

白虎加人参汤治疗肥胖症合并2型糖尿病的潜在活性成分及作用机制分析

桑叶黄酮对糖尿病小鼠胰岛素抵抗及炎症反应的作用机制

葛根芩连汤对db/db糖尿病小鼠SIRT1/FoxO1自噬通路的影响