Objective: To compare the liver-protective effects between traditional decoction and Chinese medicinal dispensing granule of Sini San. Method: Liver injury models were induced by establishing restraint stress and Propionibacterium acnes-lipopolysaccharide (LPS) in mice. Kunming mice were divided into 7 groups

normal control

stress model

positive control

Sini San decoction (600

1 200 mg · kg-1) and Sini San dispensing granule (600

1 200 mg · kg-1). Mice were administered for consecutive 6 days and restrained for 18 h. Hepatic function was evaluated by assessing assessing alanine aminotransferase(ALT) and aspartate aminotransferase (AST) level in plasma. Kuming mice were divided into 7 groups

such as normal control

P.acnes-LPS model

positive control

Sini San decoction (600

1 200 mg · kg-1) and Sini San dispensing granule (600

1 200 mg · kg-1). Mice were injected with 20 mg · kg-1 P. acnes and 5 μg · kg-1 LPS to induce liver injury. Hepatic function was evaluated by ALT and AST level in plasma. Result: Compared with the model groups

the traditional decoction and Chinese dispensing granule of Sini San significantly reduced ALT and AST levels induced by restraint stress or P.acne-LPS. However

there were no significant difference between the two samples. Conclusion: The traditional decoction and Chinese medicinal dispensing granule of Sini San both are effective on improving the liver function in liver-injury mice model.