Objective: To study the protective effect of Xueshuantong against cisplatin-induced nephrotoxicity. Method: Female SD rats were randomly divided into six groups:normal saline(NS)group

model group

positive control group and the high dose group

middle dose group and low dose group of Xueshuantong

with 12 rats in each group. The model rats with nephrotoxicity were duplicated with injection of cisplatin by vena caudalis. Rats in model group

positive control group and the high dose group

middle dose group and low dose group of Xueshuantong were treated by amifostine

0.1 mg·kg-1

Xueshuantong

15.63

31.35

62.70 mg·kg-1 once a day.The changes of serum creatinine(SCr)

blood urea nitrogen(BUN)

N-acetyl-beta-D glucosa minidase(NAG)

urine protein/24 h

the content of malondialdehyde(MDA) and the activity of superoxide dismutase(SOD)

glutathione peroxidase(GSH-Px) were measured and renal structure was observed after 10 days of administration. Result: Compared with the model group

contents of BUN

SCr in serum and urine protein /24hour

NAG in urine were significantly decreased in each treatment group (P<0.01 or P<0.05)

the content of MDA was also significantly decreased(P<0.01 or P<0.05)and the activity of SOD and GSH-Px was significantly increased (P<0.01 or P<0.05). The pathological slice indicated that renal structure was significantly improved. Conclusion: Xueshuantong can effectively relieve cisplatin-induced nephrotoxicity by reducing the pathological changes of renal structure and improving the function in renal injury rats induced by cisplatin and inhibiting the oxidative damage of kidney.