With the new materials

new technologies and new emerging carriers

the research of novel dosage form of podophyllotoxin and its derivatives is opening up a broader prospect. Relevant literatures are collected

compiled for review. The applications of podophyllotoxin in liposome nanoparticles

layered double hydroxide

drug-loaded polymer micelles

and other new drug carrier system and its anti-tumor effect were introduced. The podophyllotoxin derivatives etoposide microspheres

oral microemulsion

nano-liposomes

β-cyclodextrin and other new formulations for anti-cancer in targeted therapy

increasing the solubility of hydrophobic drugs

sustained-release effect of the drug were also introduced. Further studies on podophyllotoxin and its derivatives as novel targeted agents will reduce toxicity and enhance the characteristics of anti-tumor effect. All these could serve as referential basis for the reasonable development of podophyllotoxin and its derivatives with new formulations.