关联度最强药物配伍的中医止呕类方数据挖掘

黄颖琦; 贾恒; 何前松; 冯泳

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关联度最强药物配伍的中医止呕类方数据挖掘

更新时间：2024-01-04

- 关联度最强药物配伍的中医止呕类方数据挖掘
- Rule of Remedy for Vomiting in Science of Traditional Chinese Medicine Formu as by Data Mining Based on Both Association and Correlation Rule
- 中国实验方剂学杂志 2012年18卷第14期页码：1-4
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- 基金信息：
  
  国家自然科学基金项目(30960472/C190105);贵州省科学技术基金项目(黔科合J字[2011]2293);贵阳中医学院科研项目(贵中医院内[2011]25号)
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- 纸质出版日期：2012
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黄颖琦, 贾恒, 何前松, 等. 关联度最强药物配伍的中医止呕类方数据挖掘[J]. 中国实验方剂学杂志, 2012,18(14):1-4.

HUANG Ying-qi, JIA Heng, HE Qian-song, et al. Rule of Remedy for Vomiting in Science of Traditional Chinese Medicine Formu as by Data Mining Based on Both Association and Correlation Rule[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(14): 1-4.
黄颖琦, 贾恒, 何前松, 等. 关联度最强药物配伍的中医止呕类方数据挖掘[J]. 中国实验方剂学杂志, 2012,18(14):1-4. DOI：

HUANG Ying-qi, JIA Heng, HE Qian-song, et al. Rule of Remedy for Vomiting in Science of Traditional Chinese Medicine Formu as by Data Mining Based on Both Association and Correlation Rule[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(14): 1-4. DOI：

摘要

目的: 在古今中医文献中寻找止呕方剂配伍规律与用药特点

为中药止呕新药的开发提供理论支持。方法: 收录古今止呕类方剂985首建立止呕类方剂数据库

运用相关置信度规则

对中医止呕方剂药物配伍的数据进行挖掘

利用剪枝方法筛选关联度最强的数据。结果: 最常用的单味药物为生姜使用频率高达61.23%。关联性最强的核心药对是茯苓配伍姜半夏

其相关置信度为0.114 4。关联度最强的药组为生姜、姜半夏、茯苓。结论: 生姜、姜半夏、茯苓

其相关置信度为0.295 4是中医止呕方剂中最常合用的药物配伍

其3种药物间存在极强的关联性

张仲景创制的小半夏加茯苓汤被证实是中医止呕的核心药组。

Abstract

Objective: To look for the rules of compatibility of medicines in historical prescriptions which treat vomiting

mining out new knowledge in science of traditional Chinese medicine(TCM) formulas

providing support for making new TCM remedy for vomiting. Method: Created a TCM formulas database to treat vomiting by collecting 985 TCM formulas. A threshold level datamining method which based on both association and correlation rule is used

to mining rule of compatibility of medicines in database of historical prescriptions for vomiting. Result: The most used drug is Zingiber officinale

the using frequency of Z. officinale is 61.23%. The most association and correlation couple of drugs are Poria cocos(Schw.)Wolf and Pinellia ternate(Thunb.)Breit.the correlation-confidence of this couple is 0.114 4.The most association and correlation group of drugs are Z. officinale and P. cocos and P. ternate

the correlation-confidence of this group is 0.295 4

Conclusion: The group of drugs which contain Z. officinale. and P. ternate and P. cocos is most used to treat vomiting. The ternate added in the P. cocos soup

which is ancient famous TCM formulas created by ancient great doctor ZHANG Zhong-jing

is proved that it is the key compatibility of drugs to treat vomiting.

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