Objective: To investigate protective effects of the compatibility of paeonol and paeoniflorin on experimental myocardial ischemia in rats. Method: Using the method of ligation of left descending coronary artery the rat model of myocardial ischemia was established. Experiment group:sham group

model group

control group

paeonol 100 mg · kg-1+paeoniflorin 25 mg · kg-1

paeonol 50 mg · kg-1 +paeoniflorin 12.5 mg · kg-1

paeonol 25 mg · kg-1 +paeoniflorin 6.25 mg · kg-1. ig 10 mL · kg-1 for 5 d. Sham group and model group was given ig physiological saline. electrocardiogram(ECG)

aspartate

transaminase(AST)

crealine kinase(CK)

lactate dehydrogenase(LDH) and the myocardial infarct size were measured. Result: Compared with the model group

the S-T segment and T waves elevation levels in myocardial ischemia rats in the medium dose and high dose groups of the compatibility of paeonol and paeoniflorin were obviously reduced(P<0.05 or P<0.01).The myocardial infarct sizes were decreased(P<0.05 or P<0.01). The content of AST

CK and LDH in rat serum were reduced. Conclusion: The compatibility of paeonol and paeoniflorin can effectively protect myocardial ischemic injury of rats.