Objective: To investigate the regulating effect and mechanism of the Tibet Rhodiola crenulata on blood pressure in spontaneous hypertension rat (SHR). Method: The male SHR of 13 weeks old were randomly divided into five groups: SHR control group(0.5%CMC)

the high

middle

low dosage group of the R.Crenulata(crude drug 1.08

0.27

0.068 g·kg-1·d-1) and captopril group(0.015 g·kg-1·d-1).Twelve male Wistar-kyoto rats(WKY)were served as normal group(0.5%CMC).Different dose of Tibet R.Crenulata were administrated daily via gavage for 4 weeks.Systolic blood pressure(SBP) were measured respectively by tail-cuff technique before therapy

at the time after a single ig administration of Tibet R.Crenulata and at the time after amultiple ig adiministration. At end of the experiment

blood lipid parameters

the content of nitric oxide(NO)

the activity of superoxide dismutase(SOD) were also detected and the ratios of left ventricle wet weight/body weigh left ventricutar mass index(LVMI) were calculated. Result: The SBP level of SHR in R. crenulata treatment groups was depressed notably(P<0.05-P<0.01)

nevertheless the SBP level of SHR of model group was increased obviously comparing with normal group (P<0.01) at the time after a single ig administration of R. crenulata for 12 h and at the time after amultiple ig adiministration of Tibet R.Crenulata for 4 weeks. Compare with model group.The level of LDL-C was decreased significantly(P<0.05-P<0.01) in Rhodiola treatment groups.The level of HDL-C was obviously increased and the level of FFA was decreased significantly.The level of TC was decreased(P<0.05)in low-dose group of R.crenulata.The content of NO were increased significantly in high-dose and middle-dose group of R.Crenulata.The activity of SOD were increased significantly (P<0.05-P<0.01)in high-dose and low-dose group of R.Crenulata.LVMI were decreased significantly in R.Crenulata treatment groups. Conclusion: The hypotensive function of R. crenulata was significantly in SHR. Its mechanism may modulate the lipid metabolism

increase the content of NO

enhance the activity of SOD and improve left ventricular hypertrophy.