Objective: To study the effect of Qingfei Xiaoji decoction combined with chemotherapy on quality of life and CYFRA21-1 in advanced lung squamous cell carcinoma patients. Method: A total of 120 patients with advanced lung squamous cell carcinoma were enrolled

68 were randomized to treatment group (chemotherapy plus Qingfei Xiaoji decoction) and 52 to control group (chemotherapy). The reginen of TP/GP was taken for chemotherapy. The variation of tumor marker (CYFRA21-1) in peripheral blood and quality of life before and after therapy with Qingfei Xiaoji decoction were observed. Result: The rising rate of Karnofsky score in treatment group(57.4%) was significantly lower than in control group (38.5%)(P<0.05). The levels of CYFRA21-1 (3.45±3.32) μg·L-1 was significantly lower than before therapy(16.23±13.55) μg·L-1in treatment group (P<0.001).Meanwhile

there was no diffrence in control group(16.98±12.35 vs 13.11±10.45) μg·L-1. Conclusion: Qingfei Xiaoji decoction combined with chemotherapy can improve the quality of life and reduce the level of CYFRA21-1.