Objective: To study the effect of Dongyao Wuwei Zhixie decoction on serum levels of interleukin-1(IL-1)and interleukin-10(IL-10) in rats with intestinal ulcerative colitis and. Method: Ulcerative colitis rat model was copied by 2

4

6-TNBS. Sixty SD rats were randomly divided into normal group

model group

Dongyao Wuwei Zhixie decoction low

middle and high dose group(5.5

11

22 g·kg-1)

Mesalazie group (0.5 g·kg-1)

10 in each group. The general situation and histopathological changes were observed.The ultrastructural changes of UC model rats were investigated by transmission electron microscope and the rat serum levels of IL-1

IL-10 were detected by ELISA 10 days later. Result: Dongyao Wuwei Zhixie decoction effectively improved the serum levels of IL-10

reduced the serum levels of IL-1

and had significant effect of repairing the intestinal mucosal injury. Conclusion: Dongyao Wuwei Zhixie decoction achieves a therapeutic effect by inhibiting the production of proinflammatory cytokines IL-1 and improving the production of antiinflammatory cytokines IL-10.