Objective: To investigate effects of Erzi Capsule (EZC) on apoptosis genes in rats with spermatogenic failure and to explore the related mechanism of action for treatment of male infertility. Method: Forty male rats were randomly divided in to 4 groups:model group

control group and two EZC dose groups (4.8

2.4 g · kg-1). The rat model of spermatogenic failure was established by intraperitoneal injection of cyclophosphamide (40 mg · kg-1). The treatments were lasted for 60 days. TUNEL method was used to determine apoptosis in spermatogenic cells. Bax and Bcl-2 expressions in testis were tested by immunohistochemical method. Result: Compared with the model group

two doses of EZC group decreased apoptosis index

lowered Bax expression and increased Bcl-2 expression significantly(P<0.01). Conclusion: EZC could downregulate the expression of Bax and upregulation Bcl-2 expression

reduce the incidence of apoptosis in spermatogenic cells.