DU Mao-bo, WU Zhi-cheng, LIU Shu-zhi, et al. Evaluation ofRelease and Percutaneous Absorption for Guanxin Gel Ointment[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(11): 43-45.
DU Mao-bo, WU Zhi-cheng, LIU Shu-zhi, et al. Evaluation ofRelease and Percutaneous Absorption for Guanxin Gel Ointment[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(11): 43-45.DOI:
Objective: To evaluate in vitro release and transdermal absorption behavior of Guanxin gel ointment. Method: The content of salvianolic acid B was determined by HPLC
modified Franz diffusion cell method was applied to investigate in vitro transdermal absorption behavior of Guanxin gel ointment with isolated mouse skin as barrier. Result: In 24 hours
accumulative release rate of salvianolic acid B was 92.7%
accumulated transdermal rate of salvianolic acid B was 21.97%
transmission rate was 71.9 μg·cm-2·h. Conclusion: In vitro release and transdermal behavior of Guanxin gel ointment were all satisfied with the law of in vitro release and transdermal of Chinese medicine gel ointment.