Objective: To study the influence of Coreopsis extract eluted by 50% ethanol on antihypertension and in vivo antioxidant function of hypertension mice. Method: Hypertension model of mice were induced by giving high salinity water continuously by gastric irrigation(ig) and keeping them in low-temperature environment 4 hours a day for 20 days. Then the mice were given drug continuously by ig for 28 days

measured blood pressure

collected blood and liver

and detected the activities of SOD

MDA in serum; meanwhile the livers were sampled for measurement of MDA content

activities of SOD

GSH-Px and T-AOC. Result: Compared with blank group

the blood pressure of control group was depressed significantly; SOD

GSH-Px and T-AOC activities of control group both in serum and livers were reduced significantly

results above indicated that the model was set up successfully. The drug can depress blood pressure

increase SOD

GSH-Px and T-AOC activities

reduce the content of MDA compared with control group. Conclusion: Coreopsis extract can significantly depress blood pressure

increase the ability of antioxidant effect of hypertension mouse in vivo

and reduce oxidation injury caused by hypertension

protect blood vessel and internal organs had been injuried. All results indicated that it is one of the mechanisms of antihypertensive effects of Coreopsis extract.