Objective: Experiments were carried on to compare the antitussive

expectorant and antiasthmatic effects of Fritillaria unibracteata

F. unibracteata var.wabensis and F. thunbergii and identify if the F. unibracteata.wabensis can be used as the alternative resources of wild F. cirrhosa. Method: The antitussive effects of the 3 kinds of fritillarias s were investigated through testing the cough times and EDT50 induced by ammonium hydroxide in mice and the counts of cough induced by critic acid in guinea pigs. The expectorant activities were sdudied by testing the amount of phlegm secreted in mice and rats. The antiasthma effect was studied by the asthma time induced by acetylcholine chloride and histamine phosphate in guinea pigs.There were negative control

positive control and 3 kinds of fritillarias groups in every experiment. The dose of fritillarias in the antitussive experiment was 2.5 g·kg-1·d-1in mice and 1.5 g·kg-1·d-1in guinea pigs. The dose of 3 fritillarias in the expectorant experiment was 2 g·kg-1·d-1in mice and 1 g·kg-1·d-1 in rats

The dose of 3 kinds of fritillarias in the anti-asthma experiment was 1.5 g·kg-1·d-1. The administration time of every experiments was 5 days. Result: F. unibracteata var.wabensis cultivated has similar eliminating phlegm activities and antiasthma effects to F. unibracteata. It also has similar antitussive effects to F. unib-racteata and F. thunbergii Miq. Conclusion: F. unibract-eata var.wabensis cultivated can be used as alternative resources of wild F. cirrhosa.