Objective: To observe the effect of Yunnan Baiyao Combined with pantoprazole in treatment of acute upper digestive tract hemorrhage. Method: One hundred and twenty patients were randomly divided into the observation group and the control group

60 cases in each group. Two groups of patients after admission were treated with hemostasis

infusion and (or) transfusion. In acute period

fasting or indwelling gastric tube were carried out for patients with hematemesis. The control group at the same time give pantoprazole intravenous drip: first with pantoprazole 80 mg saline 100 mL rapid intravenous infusion

again with 8 mg·h speed continuous infusion for 3 days. In observation group

Yunnan Baiyao was orally given at the same time

0.5 g each time

6 times daily

for 3 days. The 2 groups were treated for 3 days as 1 course of treatment

the therapeutic effects were observed after 1 course of treatment. Result: The observation group showed an efficacy of 73.33%

the total effective rate was 93.33%; in the control group marked effective rate was 26.67%

the total efficacy was 70%. In two groups

the total efficacies appearred to be differences(P<0.05 ). Bleeding time

duration of hospitalization in observation group were (28.8±3.4) h

(6.68±0.5) d respectively

in control group (52.6±5.7) h

(9.33±3.2) d respectively. The data in observation group were shorter than that in control group(P<0.05 ).Volume of blood transfusion and bleeding volume in obseruation group were (14.2±3.4) U

(451.6±50.8) mL

in control group were(29.8±5.3)U

(612.3±68.5) mL (P<0.05). Serum high sensitive C reactive protein (hs-CRP) and cortisol levels after treatment were significantly reduced (P<0.05)

but the observation group were more significantly reduced (P<0.05). Conclusion: Yunnan Baiyao combined with pantoprazole in treatment of acute upper gastrointestinal hemorrhage shows remarkable clinical curative effect with shortened bleeding time and decreased amount of blood transfusion.