降压中药有效组分配伍对离体大鼠胸主动脉环的舒张作用

许激扬; 张映桥; 卞筱泓; 余涛; 许建良; 李兰娥

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降压中药有效组分配伍对离体大鼠胸主动脉环的舒张作用

更新时间：2024-01-04

- 降压中药有效组分配伍对离体大鼠胸主动脉环的舒张作用
- Vasodilative Action of Combinations of Hypotensive Components of Traditional Chinese Medicines on Rat Isolated Thoracic Aorta
- 中国实验方剂学杂志 2012年18卷第14期页码：147-151
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家自然科学基金项目(81073010)
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  中图分类号：
- 纸质出版日期：2012
- 稿件说明：
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许激扬, 张映桥, 卞筱泓, 等. 降压中药有效组分配伍对离体大鼠胸主动脉环的舒张作用[J]. 中国实验方剂学杂志, 2012,18(14):147-151.

XU Ji-yang, ZHANG Ying-qiao, BIAN Xiao-hong, et al. Vasodilative Action of Combinations of Hypotensive Components of Traditional Chinese Medicines on Rat Isolated Thoracic Aorta[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(14): 147-151.
许激扬, 张映桥, 卞筱泓, 等. 降压中药有效组分配伍对离体大鼠胸主动脉环的舒张作用[J]. 中国实验方剂学杂志, 2012,18(14):147-151. DOI：

XU Ji-yang, ZHANG Ying-qiao, BIAN Xiao-hong, et al. Vasodilative Action of Combinations of Hypotensive Components of Traditional Chinese Medicines on Rat Isolated Thoracic Aorta[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(14): 147-151. DOI：

摘要

目的: 研究天麻素、黄芩苷、川芎嗪、葛根素4种中药有效单体及其组合对大鼠胸主动脉的舒张作用

筛选出最佳组合。方法: 以大鼠胸主动脉环为标本

观察单组分及组合物对去甲肾上腺素(NE)预收缩的血管舒张作用。结果: 天麻素、黄芩苷、川芎嗪、葛根素单体存在浓度依赖性的舒张血管效应。正交实验结果显示天麻素(0.64 g·L-1)、黄芩苷(0.12 g·L-1)、川芎嗪(0.32 g·L-1)、葛根素(0.64 g·L-1)是最优组合

舒张率达到89.37%。结论: 单组分及组合物对NE预收缩的大鼠胸主动脉均具有舒张作用

组合配伍强于单组分。

Abstract

Objective: To investigate the vasodilative action of gastrodin

baicalin

tetramethylpyrazine

puerarin and their combinations on rat thoracic aorta

and to select the best combination of hypotensive components. Method: The rat thoracic aorta was taken as specimen and the vasodilative action of single components and their combinations on rat thoracic aorta which was pre-constricted with NE was tested. Result: Gastrodin

baicalin

tetramethylpyrazine and puerarin exerted a dose-dependent vasodilative action on rat isolated thoracic aorta rings. The results of orthogonal optimization experiment showed that the best combination including gastrodin (0.64 g·L-1)

baicalin (0.12 g·L-1)

tetramethylpyrazine (0.32 g·L-1) and puerarin (0.64 g·L-1) presented more obvious contraction than any single component. And the vasodilatation rate was 89.37%. Conclusion: The above components and their combination have vasodilative action on the NE pre-constricted rat thoracic aorta

but the effect of latter is stronger than the former.

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