Objective: To investigate molding process of fresh Rehmannia glutinosa formula granule. Method: Kinds and consumption of accessories were investigated with particle size

bulk density

mobility

melting and moisture absorption as indexes;The concentrations of ethanol and optimum wetting agent were investigated with soft material properties

difficulty degree of granulation

product character as indicators. Result: Optimum granulation process was:mixing ratio of dry powder-maltodextrin 1∶1

85% ethanol as wetting agent to make soft material

extrusion granulation with one drug sieve

dried at 60 ℃

sorting particle.Critical relative humidity of product particles was 60%. Conclusion: This optimized process was simple with high yield

it could provide experimental basis for large-scale production of fresh R. glutinosa formula granule.