Objective: To optimize water extraction technology of Xiaoshi Daozhi gel. Method: With the content of geniposide as index which was determined by HPLC

Agilent XDB-C18 column(4.6 mm×250 mm

5 μm)

acetonitrile-water(10∶90)as mobile phase with flow rate of 1.0 mL·min-1

UV detection wavelength was 238 nm

orthogonal test was used to optimize extraction technology of Xiaoshi Daozhi gel with water volume

extraction times and extraction time as factors. Result: Optimal water extraction technology was as follows:extracted 2 times with 6 times the amount of water

1 h per time. Conclusion: This optimized technology was simple with low cost

it was suitable for industrial production.