Objective: To prepare baicalin liposome gel and transfersome gel

and to compare in vitro transdermal property of them. Method: Baicalin liposome gel and transfersome gel were prepared with carbopol 981 as accessories

modified Franz diffusion cell was used

isolated rat skin as transdermal barrier

unit area cumulative permeation quantity of baicalin was determined by ultraviolet spectrophotometry. Result: Unit area cumulative permeation quantities of baicalein liposome gel and transfersome gel in 24 h were (38.00±2.51)

(43.27±2.39)μg·cm-2 respectively

in vitro transdermal property of them were in line with Higuchi pharmacokinetics equation. Conclusion: Without pressure

baicalin transfersome gel had similar in vitro tansdermal property with ordinary liposome gel.