Objective: To observe the effect of Xingnaojing injection combined with reduced glutathione in the treatment of hepatic encephalopathy. Method: Eighty cases of hepatic encephalopathy were randomly divided into the observation group and the control group

40 cases in each group. Two groups of patients after admission were given constraints on protein intake

removed incentives

supplement of albumin

maintained the electrolyte disorders such as symptomatic treatment. The observation group while giving the effect of Xingnaojing injection in 20 mL+250 mL 5% glucose injection

intravenous drip

1 times a day; also the prototype of valley reduced glutathione 0.6 g+250 mL intravenous saline infusion

1 times a day. The 2 groups were treated for 10 days as 1 course of treatment

after treatment the efficacy in the two groups was evaluated. Result: Significant efficiency was observed in observation group 62.50%

control group 45%(P<0.05). The total effective rate in observation group was 95%

control group 80%(P<0.05). After treatment

AST

ALT

TBil

blood ammonia level in observation group were (143.93±75.41)

(124.45±74.43)U·L-1

(155.92±71.21)

(131.43±49.16) μmol·L-1;in control group they were respectively (113.75±70.58) U·L-1

(94.32±42.64) U·L-1

(117.31±61.23)

(91.33±39.15) μmol·L-1

compared with before treatment in two groups of AST

ALT

TBil

blood ammonia levels decreased significantly (P<0.05)

the observation group was improved more than control group (P<0.05). Fever

convulsions

consciousness disturbance

meningeal irritation

cranial nerve involvement disappearance time

EEG

cerebrospinal fluid to restore the normal time

the average hospitalization time in observation group were better than those in control group (P<0.05). Conclusion: The effect of Xingnaojing injection combined with reduced glutathione for treatment of hepatic encephalopathy is significant.