The applications of brain microdialysis in pharmacokinetics in the normal brain and cerebral ischemia model were chiefly introduced.The applications include the drugs across the blood-brain barrier characteristics

drug transport

the distribution of drugs in different regions in the brain

the changes of neurotransmitters and energy metabolites

and cerebral protective effect of exogenous drugs

etc. Brain microdialysis technique can collect samples from extracellular fluid of the endogenous and exogenous compounds in the specific site continuously

and the samples can be dynamically sampled and observed. The technique has become an important research tool and presents unique advantages and prod perspective in pharmacokinetics in the normal brain and cerebral ischemia model.