Objective: To observe the hypoglycemic effect of Jingshenguo granule on type 2 diabetic rats caused by streptozotocin (STZ). Method: Type 2 diabetic rat model was established by diet of high fat combined with intraperitoneal injection of STZ. And then according to their blood glucose levels

the models were randomly divided into four groups which were model control group

Jingshenguo granule low dosage group (1.0 g·kg-1)

Jingshenguo granule high dosage group (3.0 g·kg-1)

and metformin hydrochloride group (0.3 g·kg-1). The treatment in each group was administrated ig for fourteen days. The influence from Jingshenguo granule was investigated on type 2 diabetic rats regarding weight

fast blood glucose

total cholesterol

triglyceride

high-density lipoprotein

serum insulin. Result: Low and high doses of Jingshenguo granule could significantly lower (FBG)

(TC) and (TG) (P<0.05)

and could increase (HDL-C) and (Ins) content (P<0.05) in type 2 diabetic rats after fourteen days’ medical administration compared with that of model control group (P<0.05). And Jingshenguo granule high dose group had better hypoglycemic effect than that of low dose group (P<0.05). Conclusion: Jingshenguo granule can reduce blood glucose and blood lipid in type 2 diabetic rats

which may be related to the increase of insulin sensitivity and regulation of lipids metabolism.